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Approved Medications During Pregnancy After the First Trimester
(14 weeks)

Do not take any medications (over the counter or prescription) in the first trimester other than prenatal vitamins, Tylenol and the medications listed under "Nausea" without discussing with your physician first. If you have a medical condition for which you routinely take medication, check with both the ordering physician and your obstetrician regarding continuing the medication.

Prenatal Vitamins

  • Any OTC (over the counter) prenatal vitamins. We can also give you a prescription for FREE prenatal vitamins at Meijer.
  • DHA – is an optional addition to your prenatal vitamin and can be obtained in a separate pill. DHA can be found in fish oil, some plant based vitamins and Expecta DHA.


  • Clindamycin
  • Topical erythromycin
  • Avoid: Accutane, Retin-A, Tetracycline, Minocycline


The following medications have been approved to take during pregnancy. Please take as directed by your prescribing physician.

  • Amoxicillin
  • Augmentin
  • Ceclor
  • Cephalosporins
  • Clotrimazole
  • Diflucan**
  • Erythromycin
  • Flagyl (metronidazole)**
  • Keflex
  • Macrobid/Macrodantin**
  • Metrogel
  • Miconazole (Monistat)
  • Penicillin
  • Terconazole (Terazol)
  • Zithromax
  • Avoid: Cipro, Levaquin, Minocycline, Tetracycline

**Use may be limited to certain trimesters, call office before using


  • Benadryl
  • Claritin
  • Flonase
  • Nasonex
  • Rhinocort
  • Zyrtec


  • Ferrous Sulfate
  • Feosol
  • Iron Supplements


  • Albuterol
  • Proventil
  • Ventolin

Colds/Upper Respiratory Infections

  • Benadryl
  • Dextromethorphan
  • Guaifenesin
  • Mucinex (guaifenesin)
  • Mucinex DM
  • Robitussin 12h
  • Robitussin DM
  • Robitussin Max Strength Nighttime Cough DM
  • Vicks DayQuil/NyQuil Cough
  • Vicks DayQuil Mucus Control DM
  • VapoDrops


  • Benefiber
  • Citrucel
  • Colace
  • Dulcolax suppositories
  • Fibercon
  • Glycerin suppositories
  • Metamucil
  • Miralax
  • Senokot-S


Keep hydrated and call primary care physician as needed

  • Imodium (use only if diarrhea is debilitating and for a limited time)


  • Gas-X
  • Mylicon
  • Phazyme

Headaches or Fever

  • Acetaminophen/Tylenol (Regular or extra strength). Ok to use throughout pregnancy including first trimester.


  • Maalox
  • Mylanta
  • Milk of Magnesia
  • Pepcid
  • Prevacid
  • Prilosec
  • Rolaids
  • Tums (limit 4/day)


  • Anusol/Anusol HC (Prescription Analapram 2.5%)
  • Hydrocortisone OTC
  • Preparation H
  • Tucks with witch hazel


  • Zovirax (Acyclovir)
  • Famvir (Famciclovir)
  • Valtrex (Valacyclovir)

Nasal Spray

  • Nasal saline spray


The following are ok to use throughout pregnancy including the first trimester.

  • Vitamin B6 25 mg 3 times daily
  • Unisom ½ tablet at bedtime
  • Vitamin B6 and Unisom at bedtime
  • Dramamine
  • Ginger pops or capsules 250 mg 4 times daily
  • Sea Bands – Acupressure
  • Zofran


  • Acetaminophen/Tylenol (Regular or extra strength)
  • **Narcotic medications should only be used when prescribed for a legitimate medical problem by a doctor for a short period of time


  • Benadryl cream or tablets
  • 1% Hydrocortisone cream

Sleep Aids

  • Benadryl
  • Unisom
  • Tylenol PM


  • Cepacol
  • Salt water gargle with warm water
  • Throat Lozenges

Tooth Pain

  • Oragel

Yeast Infections

  • Clotrimazole (3 or 7 days)
  • Diflucan**
  • Miconazole (Monistat-3 or 7)
  • Terconazole (Terazol-7)

**Use may be limited to certain trimesters, call the office before using. Essential oils and herbal remedies are not well studied in pregnancy and therefore not recommended.

Please ask your obstetrician if you have any specific questions regarding these.